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    You are here : Home » MS Research News » Other Conditions Research » Celiac Disease

    Celiac Disease

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    Prevalence of celiac disease in multiple sclerosis

    Celiac Disease and MSAbstract

    Background
    Celiac disease (CD) is a common systemic disease related to a permanent intolerance to gluten and is often associated with different autoimmune and neurological diseases. Its mean prevalence in the general population is 1-2% worldwide. Our aim was to study the prevalence of celiac disease in a prospective series of Multiple Sclerosis (MS) patients and their first-degree relatives.

    Methods
    We analyzed the prevalence of serological, histological and genetic CD markers in a series of 72 MS patients and in their 126 first-degree relatives, compared to 123 healthy controls.

    Results
    Tissue IgA-anti-transglutaminase-2 antibodies were positive in 7 MS patients (10%), compared to 3 healthy controls (2.4%) (p < 0.05). OR: 5.33 (CI-95%: 1.074-26.425). No differences were found in HLA-DQ2 markers between MS patients (29%) and controls (26%) (NS).

    We detected mild or moderate villous atrophy (Marsh III type) in duodenal biopsies, in 8 MS patients (11.1%). We also found a high proportion of CD among first-degree relatives: 23/126 (32%). Several associated diseases were detected, mainly dermatitis 41 (57%) and iron deficiency anemia in 28 (39%) MS patients. We also found in them, an increased frequency of circulating auto-antibodies such as anti-TPO in 19 (26%), ANA in 11 (15%) and AMA in 2 (3%).

    Conclusions
    We have found an increased prevalence of CD in 8 of the 72 MS patients (11.1%) and also in their first-degree relatives (23/126 [32%]). Therefore, increased efforts aimed at the early detection and dietary treatment of CD, among antibody-positive MS patients, are advisable.

    Full article

    Luis Rodrigo1 , Carlos Hernández-Lahoz2 , Dolores Fuentes1 , Noemí Alvarez1 , Antonio López-Vázquez3  and Segundo González3
    1  Gastroenterology, Hospital Universitario Central de Asturias (HUCA), c/Celestino Villamil, s. n°., 33006. Oviedo, Spain
    2  Neurology, Hospital Universitario Central de Asturias (HUCA), c/Celestino Villamil, s. n°., 33006. Oviedo, Spain
    3  Immunology Services Hospital Universitario Central de Asturias (HUCA), c/Celestino Villamil, s. n°., 33006. Oviedo, Spain

    Source: BMC Neurology © 1999-2011 BioMed Central Ltd (20/04/11)
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